复方罗布麻片I, Fufang Luobuma Pian I, Compound Kendir Leaves Tablets I, for Hypertension

Drug Name
Compound Kendir Leaves Tablets I
Fu Fang Luo Bu Ma Pian

Ingredients
Each tablet contains:
- Dried extract of Kendir leaves decoction: 218.5mg
- Dried extract of wild chrysanthemum decoction: 171.0mg
- Dried extract of Fangji decoction: 184.2mg
- Hydrochlorothiazide: 1.6mg
- Magnesium trisilicate: 15mg
- Dihydralazine sulfate: 1.6mg
- Promethazine hydrochloride: 1.05mg
- Vitamin B1: 0.5mg
- Vitamin B6: 0.5mg
- Calcium pantothenate: 0.25mg

Description
This product is a sugar-coated tablet. After removing the sugar coating, it appears grayish-brown, with a slight fragrance and a bitter-then-astringent taste.

Indications
For the treatment of hypertension.

Dosage and Administration
Oral administration. Take 2 tablets each time, 3 times a day. Maintenance dose: 2 tablets per day.

Adverse Reactions
No adverse reactions have been reported.

Contraindications
This product is contraindicated in patients with a hypersensitivity to it.

Precautions
1. Caution should be exercised in patients with hypertension accompanied by diabetes or gout.
2. Large doses of this product may have a central sedative effect, so caution is advised for those driving or operating machinery at heights.
3. Do not use if the appearance of the medication has changed.

Special Populations
- Children: Reduce dosage or follow medical advice.
- Pregnancy and Lactation: This product is not the preferred medication for hypertensive women during pregnancy and lactation.
- Elderly: The safety profile in elderly patients is unclear.

Drug Interactions
Overdosage of this product may cause sedation, drowsiness, fatigue, and may also increase blood uric acid levels.

Pharmacological Effects
In experimental renal hypertensive dogs, oral administration of this product at a dose of 0.2g/kg significantly reduced blood pressure, decreasing from 190/142 mmHg to 153/98 mmHg within 2 hours. At doses of 0.2 and 0.4g/kg in dogs and cats, it slowed heart rate for 5 hours after 20 minutes of administration. In rats, doses of 0.3 and 0.6g/kg significantly antagonized arrhythmias induced by aconitine, calcium chloride, and coronary artery ligation. The anti-arrhythmic mechanism may be related to affecting calcium ion influx. In mice, oral administration of 0.6 and 1.2g/kg reduced spontaneous activity and had a synergistic effect with pentobarbital sodium, causing the loss of righting reflex.

Storage
Keep tightly closed.

Packaging Specification
100 tablets per bottle.

Expiration
24 months